07:00 (IL) Israel Aug Manufacturing Production M/M: 4.7% v 0.1% prior00:14 AZN Phase 3 IMFINZI plus tarlatamab data in extensive-stage small cell lung cancer; OS HR 0.4200:10 CELC Phase 3 gedatolisib data in HR+/HER2- advanced breast cancer; PFS benefit in liver-metastasis subgroups00:09 JNJ Phase 3 apalutamide plus ADT data in high-risk localized or locally advanced prostate cancer; Recurrence or death risk -62% v surgery alone23:53 AMGN Phase 3 IMDELLTRA plus IMFINZI data in first-line maintenance ES-SCLC; Median OS 21.1 months23:13 (IR) US intelligence memo issues warning about "advanced" Iranian plots to kill American officials abroad - Axios
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(US) Reminder for US markets: today, on Dec 16th, about $4T worth in options tied to stocks, stock index futures and ETFs set to expire in quadruple witching (largest in two years)

- Primary expiry is at US Wall Street open at 09:30ET (14:30GMT)

**Note: The term "quadruple witching" denotes days when a host of equity-linked options and futures contracts expire. It only happens four times a year, once every quarter.
12:24 (US) Market Trading Hours Summary: As expected, Dec PCE runs hotter than CPI, Q4 GDP impacted by shutdown; Supreme Court strikes down IEEPA tariff powers
S&P 5007672.5 ▼1.73%EUR/USD1.12 ▲0.28%USD/JPY156.86 ▼0.9%GBP/USD1.34 ▲1.24%OIL--Gold4010 ▼16.82%